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Main Dishes • Creamy Garlic Butter Cajun Chicken Penne

Creamy Garlic Butter Cajun Chicken Penne

October 1, 2025 by Debra

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Why Creamy Garlic Butter Cajun Chicken Penne Is a Go-To Comfort Dish

A taste of Italy with a Cajun twist

Hi! I’m Sofia Russo, and my journey in cooking began in a sunlit Italian village where I fell in love with the simplicity of pasta. It wasn’t just about the flavors; it was about the love and tradition behind each dish. One afternoon, I watched a nonna expertly roll out tagliatelle, and it got me dreaming of infusing that same love into my own recipes.

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Fast forward to now, I’ve melded my experiences, and one dish that captures my heart is Creamy Garlic Butter Cajun Chicken Penne. The rich, buttery goodness of this dish reminds me of those Italian afternoons while the Cajun spices take me back to my American roots. It’s a culinary love letter that makes me feel at home wherever I am.

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A perfect blend of flavors

What I adore about Creamy Garlic Butter Cajun Chicken Penne is how it beautifully combines comforting creamy textures with the bold, zesty notes of Cajun seasoning. Each bite is a symphony of flavors, bringing together the richness of chicken and garlic butter, making it an ideal dish for gatherings or cozy nights in.

It’s all about that harmonious blend that transforms a simple meal into a delightful experience, showcasing how cooking can transcend borders and cultures. You have to try it; this dish really embraces everything I love about food!

How to Make Creamy Garlic Butter Cajun Chicken Penne

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Ingredients You’ll Need

Main Ingredients

  • 1 lb chicken breast, diced
  • 12 oz penne pasta
  • 4 tbsp unsalted butter
  • 4 cloves garlic, minced
  • 1 cup heavy cream
  • 1 cup chicken broth

Seasoning and Garnish

  • 1 tbsp Cajun seasoning
  • 1 cup grated Parmesan cheese
  • Salt and pepper to taste
  • Parsley or green onions (optional, for garnish)

Step-by-Step Instructions

Cooking the Pasta

  1. Cook the penne: In a large pot, bring salted water to a boil and cook the penne pasta according to package instructions. Drain and set aside.

Preparing the Chicken

  1. Cook the chicken: In a large skillet over medium heat, melt the butter and add the diced chicken. Season with Cajun seasoning, salt, and pepper. Cook until the chicken is browned and cooked through, approximately 5-7 minutes.

Adding Flavor

  1. Sauté the garlic: Add the minced garlic to the skillet with the chicken and sauté for about 1 minute until fragrant.

Making the Sauce

  1. Create the creamy sauce: Pour in the chicken broth and heavy cream, and bring the mixture to a gentle simmer. Stir in the grated Parmesan cheese until it melts and creates a smooth sauce.

Combining Ingredients

  1. Combine with pasta: Add the cooked penne pasta to the skillet, tossing it in the creamy sauce until well coated.

Final Touch

  1. Serve: Plate the pasta warm, garnished with parsley or green onions if desired.

Serving Creamy Garlic Butter Cajun Chicken Penne with Style

What to Serve with This Creamy Pasta

When serving Creamy Garlic Butter Cajun Chicken Penne, consider pairing it with crusty French bread or a simple mixed greens salad tossed in light vinaigrette. A crisp white wine, like Pinot Grigio, complements the flavors beautifully, enhancing this dish’s creamy richness. The balance of the creamy pasta and the freshness of the sides offers a well-rounded meal experience.

Delicious Variations Worth Trying

Feel free to customize this dish! You could add shrimp for a seafood twist, swap in turkey sausage for a lower-fat option, or even spice things up with extra Cajun seasoning if you like more heat. Each variation creates a unique experience while keeping the foundation of that creamy, garlicky goodness at the heart of the dish.

How to Store and Reheat Creamy Garlic Butter Cajun Chicken Penne

Best Way to Store and Keep Flavor

To store any leftover Creamy Garlic Butter Cajun Chicken Penne, place it in an airtight container and refrigerate for up to 3 days. Make sure to cool it completely before sealing to prevent condensation. If you want to keep it longer, you can freeze it for up to 2 months, but be aware that the creamy texture might slightly alter upon thawing.

How to Reheat Without Drying It Out

When reheating, I recommend using the stovetop method for the best results. Add a splash of chicken broth or cream to the skillet to help retain the creamy consistency. Stir over low heat until warmed through while avoiding the microwave, as it can dry out the pasta. This way, you can enjoy your Creamy Garlic Butter Cajun Chicken Penne just as deliciously as when it was first prepared!

FAQs about Creamy Garlic Butter Cajun Chicken Penne

1. Can I use a different type of pasta?

Absolutely! While penne works wonderfully, you can substitute it with any pasta shape you prefer, such as fettuccine, farfalle, or even gluten-free pasta.

2. Is there a vegetarian version of this dish?

Yes! You can replace the chicken with vegetables like bell peppers, zucchini, and mushrooms, or use plant-based proteins like tofu. Ensure to adjust the seasoning accordingly for flavor.

3. What is Cajun seasoning?

Cajun seasoning is a spice blend that typically includes paprika, oregano, thyme, garlic powder, onion powder, cayenne pepper, and black pepper. You can easily find it pre-made at the store or create your own blend at home.

4. Can I make this dish ahead of time?

Yes! You can prepare the creamy sauce and cook the pasta in advance. Combine them when you’re ready to serve, heating it up gently on the stove.

5. How do I make this dish spicier?

If you enjoy heat, consider adding a pinch of cayenne pepper or crushed red pepper flakes to the sauce. You can also use a spicier Cajun seasoning blend.

6. Can I freeze leftovers?

Yes, but keep in mind that the creamy texture may change slightly upon thawing. For best quality, store leftovers in an airtight container for up to 2 months.

Conclusion

Creamy Garlic Butter Cajun Chicken Penne is more than just a meal; it’s a celebration of flavors that marries my Italian heritage with vibrant Cajun spice. Whether you’re cooking for a family gathering, a cozy night in, or looking to impress friends at a dinner party, this dish never disappoints. It’s easy to customize, simple to prepare, and utterly satisfying. The rich and creamy sauce paired with perfectly cooked chicken and tender pasta makes it a standout choice in anyone’s recipe collection. I truly hope you try it and experience the delightful journey of flavors that this dish offers! Bon appétit!

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